Had a problem with our hspice setup, in that hspui and awaves would not run. Turns out we needed to set the following environment variables.
installdir_version d:\synopsys\Hspice_Z-2007.03 installdir_Z-2007.03 d:\synopsys\Hspice_Z-2007.03 HSP_HOME d:\synopsys\Hspice_Z-2007.03
I’m not sure that I need all of these, but after setting them, things work.